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. 2015 Sep 1;8(9):11670-4.
eCollection 2015.

Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population

Libin Yang  1 , Yongbo An  1 , Guodong Wang  1 , Tan Lu  1 , Shujuan Yang  2
Affiliations

Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population

Libin Yang et al. Int J Clin Exp Pathol. .

Abstract

The aim of this study was to investigate whether XRCC3 Thr241Met polymorphism could affect the development of osteosarcoma in a Chinese population. A total of 152 osteosarcoma patients and 304 health control subjects were included in our study. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was applied to assess the XRCC3 Thr241Met gene polymorphism. By conditional logistic regression analysis, we found that TT genotype of XRCC3 Thr241Met was associated with increased risk of osteosarcoma in codominant model (OR = 2.53, 95% CI = 1.28-5.39). Moreover, XRCC3 Thr241Met gene polymorphism was correlated with an elevated increased risk of osteosarcoma in dominant (OR = 1.55, 95% CI = 1.03-2.34) and recessive models (OR = 2.30, 95% CI = 1.16-4.56). In conclusion, we found that XRCC3 Thr241Met gene polymorphism was associated with increased risk of osteosarcoma in codominant, dominant and recessive models.

Keywords: Chinese population; XRCC3 Thr241Met; osteosarcoma; polymorphism.

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References

    1. Serlo J, Tarkkanen M, Sampo M, Vettenranta K, Riikonen P, Helenius I. Incidence, treatment and survival of paediatric patients with bone sarcomas in Finland from 1991 to 2005. Acta Paediatr. 2015;255:75–78. - PubMed
    1. Powers M, Zhang W, Lopez-Terrada D, Czerniak BA, Lazar AJ. The molecular pathology of sarcomas. Cancer Biomark. 2010;9:475–491. - PubMed
    1. Bovee JV, Hogendoorn PC. Molecular pathology of sarcomas: Concepts and clinical implications. Virchows Arch. 2010;456:193–199. - PMC - PubMed
    1. de Alava E. Molecular pathology in sarcomas. Clin Transl Oncol. 2007;9:130–144. - PubMed
    1. Dong YZ, Huang YX, Lu T. Single nucleotide polymorphism in the RECQL5 gene increased osteosarcoma susceptibility in a Chinese Han population. Genet Mol Res. 2015;14:1899–1902. - PubMed

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