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. 2013 Sep;2(3):259-62.
doi: 10.1093/jpids/pis083. Epub 2012 Sep 11.

Vancomycin Dosing Practices, Trough Concentrations, and Predicted Area Under the Curve in Children With Suspected Invasive Staphylococcal Infections

Rebecca F Chhim  1 , Sandra R Arnold  2 , Kelley R Lee  3
Affiliations

Vancomycin Dosing Practices, Trough Concentrations, and Predicted Area Under the Curve in Children With Suspected Invasive Staphylococcal Infections

Rebecca F Chhim et al. J Pediatric Infect Dis Soc. 2013 Sep.

Abstract

Recent guidelines recommend empiric vancomycin dosing of 60 mg/kg per day and consideration of higher trough concentrations (15-20 mcg/mL) in children with invasive infections. In this study, we report a retrospective review evaluating the dose/trough relationship and predicted area under the curve in pediatric patients receiving vancomycin for invasive staphylococcal infections.

Keywords: Area Under the Curve; Children; Methicillin-Resistant Staphylococcus aureus; Trough Concentration; Vancomycin.

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