Comparative Study
doi: 10.1038/339679a0.
Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2
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- PMID: 2662013
- DOI: 10.1038/339679a0
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Comparative Study
Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2
Nature.
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Abstract
Actively transcribing eukaryotic RNA polymerase II is highly phosphorylated on its repetitive carboxyl-terminal domain. We have isolated a protein kinase that phosphorylates serine residues in this repetitive domain. A component of this kinase is cdc2, the product of a cell-cycle control gene previously shown to be a component of M-phase-promoting factor and M-phase-specific histone H1 kinase. This observation suggests a role for the cdc2 protein kinase in transcriptional regulation.
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