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. 2015 Sep;19(3):178-84.
doi: 10.5213/inj.2015.19.3.178. Epub 2015 Sep 22.

The Efficacy of Continuous Positive Airway Pressure Therapy on Nocturia in Patients With Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Tao Wang  1 , Wei Huang  1 , Huantao Zong  1 , Yong Zhang  1
Affiliations

The Efficacy of Continuous Positive Airway Pressure Therapy on Nocturia in Patients With Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Tao Wang et al. Int Neurourol J. 2015 Sep.

Abstract

Purpose: To assess the efficacy of the continuous positive airway pressure (CPAP) on nocturia in patients with obstructive sleep apnea (OSA).

Methods: A literature review was performed to identify all published clinical trials of CPAP for the treatment of nocturia. The search included the following databases: MEDLINE, Embase, and the Cochrane Controlled Trials Register. The reference lists of the retrieved studies were also investigated.

Results: Five publications involving a total of 307 patients were used in the analysis, which compared the number of incidents of nocturia before and after CPAP treatment. We found that patients with OSA and nocturia who were treated with CPAP had a significant decrease in the frequency of nocturia and the volume of urine associated with it. The mean number of nocturia incidents (standardized mean difference [SMD], -2.28; 95% confidence interval [CI], -2.42 to -2.15; P<0.00001) and the associated urine volume (SMD, -183.12; 95% CI, -248.27 to -117.98; P<0.00001) indicated that CPAP was effective. Besides, the Epworth Sleepiness Scale (SMD, -5.88; 95% CI, -6.56 to -5.21; P<0.00001) and the CPAP apnea-hypopnea index (SMD, -31.57; 95% CI, -33.87 to -29.28; P<0.00001) indicated that CPAP significantly improved the quality of sleep.

Conclusions: This meta-analysis indicates that CPAP maybe an effective treatment for reducing nocturia associated with OSA and improving the quality of life of such patients.

Keywords: Clinical Trial; Continuous Positive Airway Pressure; Meta-Analysis; Nocturia; Sleep Apnea, Obstructive.

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Conflict of interest statement

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
Flowchart of the study selection.
Fig. 2.
Fig. 2.
Funnel plot of the studies represented in our meta-analysis.
Fig. 3.
Fig. 3.
Change in nocturia conditions after continuous positive airway pressure treatment versus before treatment. SD, standard deviation; CI, confidence interval; df, degrees of freedom; IV, inverse variance; Fixed, fixed effect model.
Fig. 4.
Fig. 4.
Change in night-time urine volume after continuous positive airway pressure treatment versus before treatment. SD, standard deviation; CI, confidence interval; df, degrees of freedom; IV, inverse variance; Fixed, fixed effect model.
Fig. 5.
Fig. 5.
Changes to the Epworth Sleepiness Scale and apnea-hypopnea index after continuous positive airway pressure treatment versus before treatment. SD, standard deviation; CI, confidence interval; df, degrees of freedom; IV, inverse variance; Fixed, fixed effect model.
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