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. 2013 Aug 15:12:719-32.
eCollection 2013.

Anti-apolipoprotein A-I antibodies and paraoxonase 1 activity in Systemic Lupus Erythematosus

Mohammed Mahmoud Ahmed  1 , Eman Mahmoud Elserougy  2 , Iman Ibrahim Al-Gazzar  2 , Iman Mohamed Fikry  1 , Dawoud Fakhry Habib  3 , Khaled Mohamed Younes  1 , Neveen Abd El-Hameed Salem  4
Affiliations

Anti-apolipoprotein A-I antibodies and paraoxonase 1 activity in Systemic Lupus Erythematosus

Mohammed Mahmoud Ahmed et al. EXCLI J. .

Abstract

Systemic lupus erythematosus (SLE) patients have an increased risk of atherosclerosis. Identification of at-risk patients and the pathogenesis of atherosclerosis in SLE remain elusive. Paraoxonase 1 (PON1) and anti-apolipoprotein A-I antibody (anti-Apo A-I) appear to have a potential role in premature atherosclerosis in SLE. The aim of this work was to study PON1 activity and anti-Apo A-I antibody in SLE female patients and to demonstrate their relations to disease activity as well as disease related damage. Forty SLE female patients and 40 apparently healthy volunteers were included. Anti-Apo A-I antibodies levels and PON1 activity levels were assessed. Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and systemic Lupus International Collaboration Clinics (SLICC)/American College of Rheumatology (ACR) damage index were preformed in all patients. Compared with controls, SLE patients showed significantly lower PON1 activity and significantly higher titers of anti-Apo A-I. Anti-Apo A-I antibody titers correlated inversely with PON1 activity. Elevated titers of anti-Apo A-I antibody and reduced PON activity were related to increased SLEDAI and (SLICC/ACR) damage index scores. We concluded that there is decreased PON1 activity and formation of anti-Apo A-I antibodies in female patients with SLE. SLE-disease activity assessed by SLEDAI and SLE disease related organ damage assessed by SLICC/ACR damage index are negatively correlated with PON1 activity and positively correlated with anti-Apo A-I antibodies. PON1 activity and anti-Apo A-I antibodies might be involved in the pathogenesis of atherosclerosis in SLE patients.

Keywords: SLE; anti-apolipoprotein A-I antibodies; paraoxonase 1.

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Figures

Table 1
Table 1. Demographic & laboratory characteristics of the participants
Table 2
Table 2. Main clinical data of SLE patients
Table 3
Table 3. Drugs administrated by SLE patients
Table 4
Table 4. PON1 activity and anti-Apo A-I antibody levels in SLE patients and controls
Table 5
Table 5. Correlation between PON1 activity and Anti-Apo A-I antibody levels in SLE patients and the SLEDAI and SLICC scores
Table 6
Table 6. Correlation between PON1 activity, anti-Apo A-I and the demographic characteristics and the laboratory investigations of the SLE patients
Table 7
Table 7. Correlation between PON1 activity, anti-Apo A-I, the doses and the duration of different drugs used
Table 8
Table 8. PON1 activity levels in the presence and the absence of different disease manifestations
Table 9
Table 9. Apolipoprotein A-I antibody levels in the presence and the absence of different disease manifestations
Figure 1
Figure 1. Correlation between the PON1 activity and anti-Apo A-I levels
See this image and copyright information in PMC

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