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. 2015 Aug;10(2):841-844.
doi: 10.3892/ol.2015.3289. Epub 2015 May 28.

Clinical characteristics of patients with large and deep soft tissue sarcomas

Tomoki Nakamura  1 , Akihiko Matsumine  1 , Takao Matsubara  1 , Kunihiro Asanuma  1 , Astumasa Uchida  1 , Akihiro Sudo  1
Affiliations

Clinical characteristics of patients with large and deep soft tissue sarcomas

Tomoki Nakamura et al. Oncol Lett. 2015 Aug.

Abstract

In the present study, the incidence of surgical wound complications in patients with large and deep high-grade soft tissue sarcoma (STS) was investigated. In addition, the disease-specific and event-free survival rates were examined in these patients. In total, 30 adult patients with primary high-grade deep STS with a size of 10 cm or greater were treated in the current study. Of the 30 patients, 16 (53%) developed a total of 19 wound complications. In addition, 10 cases of wound dehiscence, 5 cases of infections, 3 cases of hematomas and 1 case of lymphorrhea were reported, while 3 patients with postoperative infections underwent additional surgical treatment. Longer surgery duration was associated with wound complications (P=0.04). The disease-specific survival was 58.5% at 3 years and 46.1% at 5 years after treatment. Furthermore, local recurrence was detected in 13 patients and distant metastasis was identified in 17 patients as the first relapse. The 3- and 5-year event-free survival rates were 24.4 and 16.3%, respectively. In conclusion, patients with large and high-grade, deep STSs presented a high complication rate; therefore, careful wound care is required in these patients. Furthermore, it should be also taken into account that these patients have a greater risk of tumor-associated events and mortality.

Keywords: soft tissue sarcoma; survival; wound complication.

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Figures

Figure 1.
Figure 1.
Kaplan-Meier curve demonstrating the overall disease-specific survival of the 30 STS patients.
Figure 2.
Figure 2.
Kaplan-Meier curve demonstrating the event-free survival of the 30 STS patients.
See this image and copyright information in PMC

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