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. 2015 Sep;10(3):1385-1389.
doi: 10.3892/ol.2015.3460. Epub 2015 Jul 6.

Sarcomatoid carcinoma of the stomach: A case report and literature review

Chun-Chao Zhu  1 , Mao-Ran Li  1 , Tian-Long Lin  1 , Gang Zhao  1
Affiliations

Sarcomatoid carcinoma of the stomach: A case report and literature review

Chun-Chao Zhu et al. Oncol Lett. 2015 Sep.

Abstract

Sarcomatoid carcinoma of the stomach is a rare type of malignant tumor, characterized by distinct cellular morphology. This type of tumor is even more rare in giant size. The present study reports a case of giant sarcomatoid carcinoma, which developed in the distal stomach. A 49-year-old male underwent medical investigation for gastrointestinal hemorrhage. Endoscopic examination, computed tomography (CT) and positron emission tomography-CT scan identified a giant neoplasm, which involved the gastric antrum and body, gallbladder and hepatic flexure of the colon. Surgery was performed to excise the tumor, which was ~14×13×8 cm in size. A diagnosis of sarcomatoid carcinoma was made since the tumor was positive for epithelial markers, even within the mesenchymal elements. To the best of our knowledge, only 5 cases of sarcomatoid carcinoma of the stomach have been previously reported, and a tumor that has been able to be resected despite such a large size has never been reported.

Keywords: immunohistochemistry; sarcomatoid carcinoma; stomach.

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Figures

Figure 1.
Figure 1.
Computed tomography scan data revealed a 14 cm-diameter mass in the gastric antrum and body, which infiltrated the serosa of the stomach. In addition, the gallbladder and hepatic flexure of the colon were involved.
Figure 2.
Figure 2.
A coronal computed tomography scan of the tumor.
Figure 3.
Figure 3.
Positron emission tomography-computed tomography scan revealed a large irregular mass with abnormally high fluorodeoxyglucose metabolism in the region of distal stomach, gallbladder fossa and hepatic tissue in the vicinity.
Figure 4.
Figure 4.
A lymph node with high fluorodeoxyglucose metabolism was observed in the region of the pancreatic head.
Figure 5.
Figure 5.
Endoscopic survey of the upper gastrointestinal tract identified an irregularly shaped lesion on the antrum and body.
Figure 6.
Figure 6.
Macropathological findings of the resected specimen revealed a mass with an irregular surface, measuring 14×13×8 cm in size.
Figure 7.
Figure 7.
Tumor cells demonstrated spindle-shaped structures, significant atypical nuclei, pleomorphic nuclei and giant nuclei. Cells were stained with hematoxylin and eosin stain (magnification, x400).
Figure 8.
Figure 8.
Tumor cells positive for Vimentin (magnification, x200).
Figure 9.
Figure 9.
Tumor cells positive for cytokeratin 7 (magnification, x200).
Figure 10.
Figure 10.
Tumor cells positive for CD68 (magnification, x200).
Figure 11.
Figure 11.
Tumor cells positive for Ki-67 (magnification, x200).
See this image and copyright information in PMC

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