Hodgkin's lymphoma associated with myelofibrosis: A case report

Abstract

In the present study, the case of a patient with nodular sclerosing Hodgkin's lymphoma (NSHL) presenting with diffuse fibrosis of the bone marrow (BM) was reported. A 30-year-old male complained of fever for 1 year, as well as lumbago, lymph node swelling and night sweats for 3 months. A biopsy of the lymph nodes established a diagnosis of NSHL. Aspiration of BM was a dry tap, and the BM biopsy demonstrated marked myelofibrosis with increased proliferation of reticulin fiber. Multiple skeletal lesions were detected in the patient's vertebra, pelvis, sternum and bilateral femur by magnetic resonance imaging and computed tomography. Following numerous courses of chemotherapy and radiotherapy, remission of the lymphoma was achieved. Subsequently, the BM aspiration became possible, and BM biopsy demonstrated a reduction in fibrosis.

Keywords: Hodgkin's lymphoma; myelofibrosis.

Figure 1.

Microscopic view of the lymph node biopsy specimen, diagnosed with nodular sclerosing Hodgkin's lymphoma (magnification, x40; stain, hematoxylin and eosin).

Figure 2.

Microscopic view of the bone marrow biopsy specimen, diagnosed with myelofibrosis. Increased proliferation of fibroblasts and reticulin fiber is observed (magnification, x40; stain, hematoxylin and eosin).