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Review
. 2015 Oct;7(10):E395-401.
doi: 10.3978/j.issn.2072-1439.2015.10.03.

Pre-analytic variability in cardiovascular biomarker testing

Roberto Cemin  1 , Massimo Daves  1
Affiliations
Review

Pre-analytic variability in cardiovascular biomarker testing

Roberto Cemin et al. J Thorac Dis. 2015 Oct.

Abstract

The impact of laboratory medicine on clinical cardiology has dramatically increased over the years and a lot of cardiovascular biomarkers have been recently proposed. In order to avoid clinical mistakes, physicians should be well aware of all the aspects, which could affect the quality of laboratory results, remembering that pre-analytic variability is an often overlooked significant source of bias, determining the vast majority of laboratory errors. This review addresses the determinants of pre-analitycal variability in cardiovascular biomarker testing, focusing on the most widespread biomarkers, which are cardiac troponins and natriuretic peptides.

Keywords: Laboratory variability; biomarker; cardiology.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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