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Figure 1. Schematic representation of the 6 different ZNHIT proteins found in human, with indication…
Figure 1. Schematic representation of the 6 different ZNHIT proteins found in human, with indication of the HIT (green) and other domains
Most ZNHIT proteins bind to components of cellular machineries in which RUVBL1/2 appear to play a key role, either as an assembly cofactor (box C/D snoRNPs) or as an integral part of the purified complex (Ino80, SWR1), as indicated.