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Review
. 2016 Apr;48(4):251-261.
doi: 10.3109/23744235.2015.1113438. Epub 2015 Dec 1.

Treatment of hepatitis C virus infection for adults and children: Updated Swedish consensus recommendations

Martin Lagging  1 , Rune Wejstål  1   2 , Gunnar Norkrans  1 , Olle Karlström  3 , Soo Aleman  4 , Ola Weiland  4 , Maria Castedal  5 , Filip Josephson  3 ; Swedish Consensus Group
Affiliations
Review

Treatment of hepatitis C virus infection for adults and children: Updated Swedish consensus recommendations

Martin Lagging et al. Infect Dis (Lond). 2016 Apr.

Abstract

In a recent expert meeting, Swedish recommendations for the treatment of HCV infection were updated. An interferon-free combination of direct-acting antiviral agents was recommended as the first line standard-of-care treatment for chronic HCV infection. Interferon-based therapy should be considered as a second line option after an individual benefit-risk assessment. Treatment is strongly recommended for HCV infected patients with bridging fibrosis or cirrhosis (Metavir stages F3-4), before and after liver transplantation, and in the presence of extra-hepatic manifestations. Additionally, patients with moderate liver fibrosis (stage F2) as well as women in need of in vitro fertilisation should be prioritised for therapeutic intervention. Treatment indications for people who inject drugs, children, chronic kidney disease and HIV co-infection are also discussed.

Keywords: DAA, people who inject drugs; HCV; HIV co-infection; Hepatitis C virus; children; chronic kidney disease; direct-acting antiviral agents; guidelines.

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