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Case Reports
. 2016 Jan-Feb;39(1):60-1.
doi: 10.1097/WNF.0000000000000116.

Reversible Fluoxetine-Induced Hyperthyroidism: A Case Report

Jianbo Lai  1 , Dongrong Xu, Bradley S Peterson, Yi Xu, Ning Wei, Minming Zhang, Shaohua Hu
Affiliations
Case Reports

Reversible Fluoxetine-Induced Hyperthyroidism: A Case Report

Jianbo Lai et al. Clin Neuropharmacol. 2016 Jan-Feb.

Abstract

Background: Selective serotonin reuptake inhibitors (SSRIs) are typically used as antidepressants. Clinically significant SSRI-induced thyroid dysfunction is rare.

Case: We report a case of hyperthyroidism induced by fluoxetine in a female patient with major depressive disorder. Her thyroid profiles indicated hyperthyroidism after a 10-week treatment with fluoxetine and were restored after discontinuation of fluoxetine and administration with venlafaxine. In the first year of follow-up, her thyroid functions as well as her depressive symptoms remained perfectly normal.

Conclusions: This case highlights the necessity of monitoring thyroid profiles during SSRI treatment.

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Conflict of interest statement

Conflicts of Interest and Source of Funding: The authors have no conflicts of interest to declare.

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