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Comment
. 2015 Dec 1;21(23):5185-7.
doi: 10.1158/1078-0432.CCR-14-3130.

CCR 20th Anniversary Commentary: Molecular Pathology of ALK-Rearranged Lung Tumors

A John Iafrate  1
Affiliations
Comment

CCR 20th Anniversary Commentary: Molecular Pathology of ALK-Rearranged Lung Tumors

A John Iafrate. Clin Cancer Res. .

Abstract

The article by Rodig and colleagues, which was published in the August 15, 2009, issue of Clinical Cancer Research, helped detail the clinicopathologic profile of ALK-positive tumors and initiated the development of ALK diagnostics. Subsequent clinical trials utilized these findings, resulting in the approval of effective targeted therapies. The ALK story is a model for the development of therapies in the genomic era.

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