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Observational Study
. 2015 Dec 1:12:226.
doi: 10.1186/s12974-015-0444-z.

Low serum ficolin-3 levels are associated with severity and poor outcome in traumatic brain injury

Jian-Wei Pan  1 , Xiong-Wei Gao  2 , Hao Jiang  3 , Ya-Feng Li  4 , Feng Xiao  5 , Ren-Ya Zhan  6
Affiliations
Observational Study

Low serum ficolin-3 levels are associated with severity and poor outcome in traumatic brain injury

Jian-Wei Pan et al. J Neuroinflammation. .

Abstract

Background: Ficolin-mediated activation of the lectin pathway of complement contributes to the complement-independent inflammatory processes of traumatic brain injury. Lower serum ficolin-3 levels have been demonstrated to be highly associated with unfavorable outcome after ischemic stroke. This prospective observatory study was designed to investigate the relationships between serum ficolin-3 levels and injury severity and clinical outcomes after severe traumatic brain injury.

Methods: Serum ficolin-3 levels of 128 patients and 128 healthy controls were measured by sandwich immunoassays. An unfavorable outcome was defined as Glasgow Outcome Scale score of 1-3. Study endpoints included mortality at 1 week and 6 months and unfavorable outcome at 6 months after head trauma. Injury severity was assessed by Glasgow Coma Scale score. Multivariate logistic models were structured to evaluate the relationships between serum ficolin-3 levels and study endpoints and injury severity.

Results: Compared with the healthy controls, serum ficolin-3 levels on admission were statistically decreased in patients with severe traumatic brain injury. Serum ficolin-3 levels were independently correlated with Glasgow Coma Scale scores. Ficolin-3 was also identified as an independent prognostic predictor for 1-week mortality, 6-month mortality, and 6-month unfavorable outcome. Under receiver operating characteristics curves, ficolin-3 has similar prognostic predictive values for all study endpoints compared with Glasgow Coma Scale scores.

Conclusions: It was proposed that lower serum ficolin-3 levels, correlated with injury severity, had the potential to be the useful, complementary tool to predict short- or long-term clinical outcomes after severe traumatic brain injury.

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Figures

Fig. 1
Fig. 1
Graph showing change of serum ficolin-3 levels after severe traumatic brain injury
Fig. 2
Fig. 2
Graph showing the relationships between serum ficolin-3 levels and Glasgow Coma Scale scores as well as between serum ficolin-3 levels and plasma C-reactive protein levels after severe traumatic brain injury
See this image and copyright information in PMC

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