Forty-five years of cell-cycle genetics

Brian J Reid¹, Joseph G Culotti², Robert S Nash³, John R Pringle⁴

Affiliations

¹ Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109 Departments of Genome Sciences and Medicine, University of Washington, Seattle, WA 98195.
² Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1X5, Canada.
³ Saccharomyces Genome Database, Stanford University School of Medicine, Stanford, CA 94305 Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305.
⁴ Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 jpringle@stanford.edu.

PMID: 26628751
PMCID: PMC4666127
DOI: 10.1091/mbc.E14-10-1484

Forty-five years of cell-cycle genetics

Brian J Reid et al. Mol Biol Cell. 2015.

. 2015 Dec 1;26(24):4307-12.

doi: 10.1091/mbc.E14-10-1484.

Authors

Brian J Reid¹, Joseph G Culotti², Robert S Nash³, John R Pringle⁴

Affiliations

¹ Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109 Departments of Genome Sciences and Medicine, University of Washington, Seattle, WA 98195.
² Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1X5, Canada.
³ Saccharomyces Genome Database, Stanford University School of Medicine, Stanford, CA 94305 Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305.
⁴ Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 jpringle@stanford.edu.

PMID: 26628751
PMCID: PMC4666127
DOI: 10.1091/mbc.E14-10-1484

Abstract

In the early 1970s, studies in Leland Hartwell's laboratory at the University of Washington launched the genetic analysis of the eukaryotic cell cycle and set the path that has led to our modern understanding of this centrally important process. This 45th-anniversary Retrospective reviews the steps by which the project took shape, the atmosphere in which this happened, and the possible morals for modern times. It also provides an up-to-date look at the 35 original CDC genes and their human homologues.

© 2015 Reid et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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References

1. Bücking-Throm E, Duntze W, Hartwell LH, Manney TR. Reversible arrest of haploid yeast cells at the initiation of DNA synthesis by a diffusible sex factor. Exp Cell Res. 1973;76:99–110. - PubMed
1. Byers B, Goetsch L. Duplication of spindle plaques and integration of the yeast cell cycle. Cold Spring Harbor Symp Quant Biol. 1974;38:123–131. - PubMed
1. Byers B, Goetsch L. Behavior of spindles and spindle plaques in the cell cycle and conjugation of Saccharomyces cerevisiae. J Bacteriol. 1975;124:511–523. - PMC - PubMed
1. Culotti J, Hartwell LH. Genetic control of the cell division cycle in yeast. III. Seven genes controlling nuclear division. Exp Cell Res. 1971;67:389–401. - PubMed
1. Dulbecco R, Hartwell LH, Vogt M. Induction of cellular DNA synthesis by polyoma virus. Proc Natl Acad Sci USA. 1965;53:403–410. - PMC - PubMed

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Forty-five years of cell-cycle genetics

Affiliations

Forty-five years of cell-cycle genetics

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Molecular Biology Databases