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. 2015 Sep 15;8(9):15222-9.
eCollection 2015.

Modified glasgow prognostic score as a prognostic factor in gastriccancer patients: a systematic review and meta-analysis

Xinwu Zhang  1 , Xi Chen  1 , Tao Wu  1 , Yan Zhang  1 , Kun Yan  1 , Xiaoli Sun  1
Affiliations

Modified glasgow prognostic score as a prognostic factor in gastriccancer patients: a systematic review and meta-analysis

Xinwu Zhang et al. Int J Clin Exp Med. .

Abstract

Objective: Modified Glasgow prognostic score (mGPS) had been reported to associate with the prognosis ofgastric cancer (GC), butits significance in gastric cancer patients has not been studied fully.

Methods: PubMed; EMBASE; Web of Science and CNKI data base were searched to identify studies using the mGPS in gastric cancer patients. Outcome measures that were evaluated included overall survival (OS), lymphatic invasion and venous invasion inpatients with gastric cancer.

Results: A total of seven studies comprising 3206 patients were included in the meta-analysisof which all used OS as an outcome measure, three studies reported lymphatic invasionand three evaluated venous invasion. The results show that OS was worse in patients with an mGPS=1 and 2 (odds ratio [OR]=2.54, 95% [CI]: 1.62-3.98 and OR=12.02, 95% [CI]: 6.79-21.28, respectively) compared with those with a score of 0 (both P<0.01). Furthermore, gastric cancer patients with mGPS≥1 have higher rates of lymphatic and venous invasion with ORs of 2.51 (95% CI: 1.80-3.51) and 2.63 (95% CI: 1.35-5.11) respectively (both P<0.01).

Conclusions: Them GPS could be used as a prognosis predictorfor gastric cancer patients and associated lymphatic and venous invasion.

Keywords: gastric cancer; mGPS; meta-analysis; prognostic factor.

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Figures

Figure 1
Figure 1
Flow diagram for inclusion of studies included in the meta-analysis.
Figure 2
Figure 2
Forest plots of studies evaluating overall survival and modified Glasgow Prognostic Score (mGPS). Overall survival in gastric cancer patients with (A) a mGPS score of 1 and (B) a mGPS score of 2 compared with patients with a mGPS score of 0. CI: confidence interval.
Figure 3
Figure 3
Forest plots of studies evaluating lymphatic invasion and modified Glasgow Prognostic Score (mGPS). Lymphatic invasionin gastric cancer patients with an mGPS score ≥1 compared with patients with a mGPS score of 0. CI: confidence interval.
Figure 4
Figure 4
Forest plots of studies evaluating venous invasion and modified Glasgow Prognostic Score (mGPS). Venous invasionin gastric cancer patients with a mGPS score ≥1 compared with patients with a mGPS score of 0. CI: confidence interval.
Figure 5
Figure 5
Funnel plot for evaluation OS of publication bias. mGPS 0 and mGPS1 (A) and mGPS 0 and mGPS2 (B). OR: odds ratio.
See this image and copyright information in PMC

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