Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Sep 15;8(9):16520-7.
eCollection 2015.

Association between ErbB3 genetic polymorphisms and coronary artery disease in the Han and Uyghur populations of China

Buamina Maitusong  1 , Xiang Xie  1 , Yi-Tong Ma  2 , Zhen-Yan Fu  2 , Yi-Ning Yang  2 , Xiao-Mei Li  2 , Fen Liu  3 , Bang-Dang Chen  3 , Min-Tao Gai  3
Affiliations

Association between ErbB3 genetic polymorphisms and coronary artery disease in the Han and Uyghur populations of China

Buamina Maitusong et al. Int J Clin Exp Med. .

Abstract

Background: ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. Recent research has shown that amplification of this gene is related to prostate, bladder and breast cancers, as well as low-density lipoprotein cholesterol (LDL-C) metabolism. LDL-C plays a considerable role in the development of cardiovascular disease. Thus, the present study assessed the association between human ErbB3 gene polymorphisms and coronary artery disease (CAD) in Han and Uygur populationsin China.

Methods: We performed two independent case-control studies with a Han population (339 CAD patients and 395 control subjects) and a Uygur population (306 CAD patients and 325 control subjects). All of the CAD patients and controls were genotyped for the same three single nucleotide polymorphisms (rs877636, rs705708, and rs10783779) in the ErbB3 gene by real-time PCR.

Results: In the Han population, rs877636 polymorphisms were associated with CAD on the basis of the genotypes, dominant model, additive model, and allele frequency (for genotypes: P = 0.008; for dominant model: P = 0.003; for additive model: P = 0.004; for allele: P = 0.008), and these significant difference was retained (all P < 0.05) after adjusting for the major confounding factors.

Conclusion: The CT genotype and C allele of rs877636 in the ErbB3 gene could be a genetic marker of CAD risk for the Han population in China.

Keywords: ErbB3; SREBF2; case-control study; coronary artery disease; single nucleotide polymorphism.

PubMed Disclaimer

References

    1. Lopez AC, Ezzati MM, et al. Global Burden of Disease and Risk Factors. Washington DC, USA: World Health Organisation; 2006.
    1. McGill HC Jr, McMahan CA, Herderick EE, Tracy RE, Malcom GT, Zieske AW, Strong JP. Effects of coronary heart disease risk factors on atherosclerosis of selected regions of the aorta and right coronary artery. PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth. Arterioscler Thromb Vasc Biol. 2000;20:836–845. - PubMed
    1. Kushwaha RS, McGill HC Jr. Diet, plasma lipoproteins and experimental atherosclerosis in baboons (Papio sp.) Hum Reprod Update. 1998;4:420–429. - PubMed
    1. Libby P. Atherosclerosis: disease biology affecting the coronary vasculature. Am J Cardiol. 2006;98:3Q–9Q. - PubMed
    1. Barter PJ, Rye KA. Molecular mechanisms of reverse cholesterol transport. Curr Opin Lipidol. 1996;7:82–87. - PubMed