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. 2015 Summer;4(3):188-95.

Impact of Propionic Acid on Liver Damage in Rats

Sooad Al-Daihan  1 , Ramesa Shafi Bhat  1
Affiliations

Impact of Propionic Acid on Liver Damage in Rats

Sooad Al-Daihan et al. Int J Mol Cell Med. 2015 Summer.

Abstract

Propionic acid (PA) is a short chain fatty acid, a common food preservative and metabolic end product of enteric bacteria in the gut. The present study was undertaken to investigate the effect of PA on liver injury in male rats. Male western albino rats were divided into two groups. The first group served as normal control, the second was treated with PA. The activities of serum hepatospecific markers such as aspartate transaminase, alanine transaminase, and alkaline phosphatase were estimated. Antioxidant status in liver tissues was estimated by determining the level of lipid peroxidation and activities of enzymatic and non-enzymatic antioxidants. Sodium and potassium levels were also measured in liver tissue. PA treatment caused significant changes in all hepatospecific markers. Biochemical analysis of liver homogenates from PA-treated rats showed an increase in oxidative stress markers like lipid peroxidation and lactate dehydrogenase, coupled with a decrease in glutathione, vitamin C and glutathione S- transferase. However, PA exposure caused no change in sodium and potassium levels in liver tissue. Our study demonstrated that PA persuade hepatic damage in rats.

Keywords: Propionic acid; liver; oxidative stress.

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Figures

Fig. 1
Fig. 1
Percentage change of all parameters in PA group compared to control.
See this image and copyright information in PMC

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