Large Scale Genetic Research on Neuropsychiatric Disorders in African Populations is Needed

Shareefa Dalvie¹, Nastassja Koen², Laramie Duncan³, Catherine Abbo⁴, Dickens Akena⁴, Lukoye Atwoli⁵, Bonginkosi Chiliza⁶, Kirsten A Donald⁷, Eugene Kinyanda⁸, Christine Lochner⁹, Sumaya Mall¹⁰, Noeline Nakasujja⁴, Charles R Newton¹¹, Raj Ramesar¹², Goodman Sibeko¹⁰, Solomon Teferra¹³, Dan J Stein², Karestan C Koenen¹⁴

Affiliations

¹ MRC/UCT Human Genetics Research Unit, Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa ; Department of Psychiatry and Mental Health, University of Cape Town, Observatory, Cape Town, South Africa.
² Department of Psychiatry and Mental Health, University of Cape Town, Observatory, Cape Town, South Africa ; Medical Research Council (MRC) Unit on Anxiety and Stress Disorders, Cape Town, South Africa.
³ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA ; Stanley Center for Psychiatric Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA ; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁴ Department of Psychiatry, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
⁵ Department of Mental Health, School of Medicine, Moi University College of Health Sciences, Eldoret, Kenya.
⁶ Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, Western Cape, South Africa.
⁷ Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
⁸ Department of Psychiatry, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda ; MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.
⁹ Medical Research Council (MRC) Unit on Anxiety and Stress Disorders, Cape Town, South Africa ; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, Western Cape, South Africa.
¹⁰ Department of Psychiatry and Mental Health, University of Cape Town, Observatory, Cape Town, South Africa.
¹¹ KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya ; Department of Psychiatry, University of Oxford, Oxford, UK.
¹² MRC/UCT Human Genetics Research Unit, Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.
¹³ Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
¹⁴ Stanley Center for Psychiatric Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA ; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA ; Psychiatric and Neurodevelopmental Genetics Unit and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.

PMID: 26629498
PMCID: PMC4634677
DOI: 10.1016/j.ebiom.2015.10.002

Large Scale Genetic Research on Neuropsychiatric Disorders in African Populations is Needed

Shareefa Dalvie et al. EBioMedicine. 2015.

. 2015 Oct 9;2(10):1259-61.

doi: 10.1016/j.ebiom.2015.10.002. eCollection 2015 Oct.

Authors

Affiliations

¹ MRC/UCT Human Genetics Research Unit, Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa ; Department of Psychiatry and Mental Health, University of Cape Town, Observatory, Cape Town, South Africa.
² Department of Psychiatry and Mental Health, University of Cape Town, Observatory, Cape Town, South Africa ; Medical Research Council (MRC) Unit on Anxiety and Stress Disorders, Cape Town, South Africa.
³ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA ; Stanley Center for Psychiatric Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA ; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁴ Department of Psychiatry, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
⁵ Department of Mental Health, School of Medicine, Moi University College of Health Sciences, Eldoret, Kenya.
⁶ Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, Western Cape, South Africa.
⁷ Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
⁸ Department of Psychiatry, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda ; MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.
⁹ Medical Research Council (MRC) Unit on Anxiety and Stress Disorders, Cape Town, South Africa ; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, Western Cape, South Africa.
¹⁰ Department of Psychiatry and Mental Health, University of Cape Town, Observatory, Cape Town, South Africa.
¹¹ KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya ; Department of Psychiatry, University of Oxford, Oxford, UK.
¹² MRC/UCT Human Genetics Research Unit, Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.
¹³ Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
¹⁴ Stanley Center for Psychiatric Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA ; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA ; Psychiatric and Neurodevelopmental Genetics Unit and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.

PMID: 26629498
PMCID: PMC4634677
DOI: 10.1016/j.ebiom.2015.10.002

No abstract available

Keywords: Africa; Genetics; Neuropsychiatry; Psychiatry.

PubMed Disclaimer

Figures

**Fig. 1**
Proportion of world population groups in psychiatric GWAS. (a) Proportion investigated in the largest meta-analyses published prior to 2015 for four leading psychiatric disorders (schizophrenia (Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014), bipolar disorder (Psychiatric GWAS Consortium Bipolar Disorder Working Group, 2011), major depressive disorder (Ripke et al., 2013), and ADHD (Neale et al., 2010); total N = 121,985). (b) Proportion investigated in PGC-PTSD studies (total N = 20,468).

See this image and copyright information in PMC

References

1. Campbell M.C., Tishkoff S.A. African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping. Annu. Rev. Genomics Hum. Genet. 2008;9:403–433. - PMC - PubMed
1. De Vries J., Bull S.J., Doumbo O., Ibrahim M., Mercereau-Puijalon O., Kwiatkowski D. Ethical issues in human genomics research in developing countries. BMC Med. Ethics. 2011;12 (5–6939-12-5) - PMC - PubMed
1. Gurdasani D., Carstensen T., Tekola-Ayele F., Pagani L., Tachmazidou I., Hatzikotoulas K. The African Genome Variation Project shapes medical genetics in Africa. Nature. 2015;517:327–332. - PMC - PubMed
1. Kolassa I., Kolassa S., Ertl V., Papassotiropoulos A., Dominique J. The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-O-methyltransferase Val 158 Met polymorphism. Biol. Psychiatry. 2010;67:304–308. - PubMed
1. Neale B.M., Medland S., Ripke S., Anney R.J., Asherson P., Buitelaar J. Case–control genome-wide association study of attention-deficit/hyperactivity disorder. J. Am. Acad. Child Adolesc. Psychiatry. 2010;49:906–920. - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Large Scale Genetic Research on Neuropsychiatric Disorders in African Populations is Needed

Affiliations

Large Scale Genetic Research on Neuropsychiatric Disorders in African Populations is Needed

Authors

Affiliations

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical