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Review
. 2015;13(6):802-14.
doi: 10.2174/1570159x13666150612225836.

The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic Studies

Arqam Qayyum, Clement C Zai, Yuko Hirata, Arun K Tiwari, Sheraz Cheema, Behdin Nowrouzi, Joseph H Beitchman, James L Kennedy  1
Affiliations
Review

The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic Studies

Arqam Qayyum et al. Curr Neuropharmacol. 2015.

Abstract

Aggressive behaviors have become a major public health problem, and early-onset aggression can lead to outcomes such as substance abuse, antisocial personality disorder among other issues. In recent years, there has been an increase in research in the molecular and genetic underpinnings of aggressive behavior, and one of the candidate genes codes for the catechol-O-methyltransferase (COMT). COMT is involved in catabolizing catecholamines such as dopamine. These neurotransmitters appear to be involved in regulating mood which can contribute to aggression. The most common gene variant studied in the COMT gene is the Valine (Val) to Methionine (Met) substitution at codon 158. We will be reviewing the current literature on this gene variant in aggressive behavior.

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References

    1. Shepherd J.P., Shepherd I., Newcombe R.G., Farrington D. Impact of antisocial lifestyle on health: chronic disability and death by middle age. J. Public Health (Oxf.) 2009;31(4):506–511. doi: 10.1093/pubmed/fdp054. - DOI - PubMed
    1. Hodgins S., Cree A., Alderton J., Mak T. From conduct disorder to severe mental illness: associations with aggressive behaviour, crime and victimization. Psychol. Med. 2008;38(7):975–987. doi: 10.1017/S0033291707002164. - DOI - PubMed
    1. Hodgins S., Alderton J., Cree A., Aboud A., Mak T. Aggressive behaviour, victimization and crime among severely mentally ill patients requiring hospitalisation. Br. J. Psychiatry. 2007;191:343–350. doi: 10.1192/bjp.bp.106.06.029587. - DOI - PubMed
    1. Mendes D.D., Mari Jde.J., Singer M., Barros G.M., Mello A.F. [Study review of biological, social and environmental factors associated with aggressive behavior]. Rev. Bras. Psiquiatr. 2009;31(Suppl. 2):S77–S85. doi: 10.1590/S1516-44462009000600006. [Study review of biological, social and environmental factors associated with aggressive behavior]. - DOI - PubMed
    1. Veenema A.H. Early life stress, the development of aggression and neuroendocrine and neurobiological correlates: what can we learn from animal models? Front. Neuroendocrinol. 2009;30(4):497–518. doi: 10.1016/j.yfrne.2009.03.003. - DOI - PubMed

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