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Comment
. 2015 Dec 15;112(50):15265-6.
doi: 10.1073/pnas.1521023112. Epub 2015 Dec 2.

How MutS finds a needle in a haystack

Mark D Sutton  1
Affiliations
Comment

How MutS finds a needle in a haystack

Mark D Sutton. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Conflict of interest statement: M.D.S. disclosed during his review of the paper by Liao and coworkers (which this Commentary addresses) that he and L. A. Simmons are coauthors on a recent paper from the A. Guarné laboratory in Nucleic Acids Research, but this paper represents work they each did independently with A. Guarné and does not represent a collaboration between L. A. Simmons and M.D.S. Although M.D.S. currently collaborates with A. Guarné, he has not and does not currently collaborate with L. A. Simmons or J. S. Biteen.

Figures

Fig. 1.
Fig. 1.
A model for B. subtilis MMR. MutS-ADP is recruited to replication forks through interactions with the replication machinery. Once recruited, MutS releases hold of the replication machinery to perform a 1D search for replication errors. After binding a mismatch, MutS exchanges ADP for ATP, recruits MutL, and then slides away from the mismatch searching for one or more strand discrimination signals.
See this image and copyright information in PMC

Comment on

References

    1. Kunkel TA, Erie DA. Eukaryotic mismatch repair in relation to DNA replication. Annu Rev Genet. 2015;49:291–313. - PMC - PubMed
    1. Fishel R, et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell. 1993;75(5):1027–1038. - PubMed
    1. Gutierrez A, et al. β-Lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity. Nat Commun. 2013;4:1610. - PMC - PubMed
    1. Foti JJ, Devadoss B, Winkler JA, Collins JJ, Walker GC. Oxidation of the guanine nucleotide pool underlies cell death by bactericidal antibiotics. Science. 2012;336(6079):315–319. - PMC - PubMed
    1. Gorman J, et al. Dynamic basis for one-dimensional DNA scanning by the mismatch repair complex Msh2-Msh6. Mol Cell. 2007;28(3):359–370. - PMC - PubMed

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