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Meta-Analysis
. 2015 Dec 3:5:17903.
doi: 10.1038/srep17903.

Prognostic Value of Ezrin in Various Cancers: A Systematic Review and Updated Meta-analysis

Jianwei Li  1 , Kuanhai Wei  1 , Hailang Yu  2 , Dan Jin  1 , Gang Wang  1 , Bin Yu  1
Affiliations
Meta-Analysis

Prognostic Value of Ezrin in Various Cancers: A Systematic Review and Updated Meta-analysis

Jianwei Li et al. Sci Rep. .

Abstract

More and more studies have investigated the effects of Ezrin expression level on the prognostic role in various tumors. However, the results remain controversial rather than conclusive. Here, we performed a systematic review and meta-analysis to evaluate the correlation of Ezrin expression with the prognosis in various tumors. the pooled hazard ratios (HR) with the corresponding 95% confidence intervals (95% CI) were calculated to evaluate the degree of the association. The overall results of fifty-five studies with 6675 patients showed that elevated Ezrin expression was associated with a worse prognosis in patients with cancers, with the pooled HRs of 1.86 (95% CI: 1.51-2.31, P < 0.001) for over survival (OS), 2.55 (95% CI: 2.14-3.05, P < 0.001) for disease-specific survival (DFS) and 2.02 (95% CI: 1.13-3.63, P = 0.018) for disease-specific survival (DSS)/metastasis-free survival (MFS) by the random, fixed and random effect model respectively. Similar results were also observed in the stratified analyses by tumor types, ethnicity background and sample source. This meta-analysis suggests that Ezrin may be a potential prognostic marker in cancer patients. High Ezrin is associated with a poor prognosis in a variety of solid tumors.

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Figures

Figure 1
Figure 1. Forrest plots of studies evaluating HRs of Ezrin expression for OS.
The squares and horizontal lines correspond to the study-specific HR and 95% CI. The area of the squares reflects the study-specific weight (inverse of the variance). The diamonds represent the pooled HR and 95% CI.
Figure 2
Figure 2. Forrest plots of studies evaluating HRs of Ezrin expression for DFS and DSS/MFS.
The squares and horizontal lines correspond to the study-specific HR and 95% CI. The area of the squares reflects the study-specific weight (inverse of the variance). The diamonds represent the pooled HR and 95% CI.
Figure 3
Figure 3. Forest plot of overall survival associated with Ezrin in cancer patients among Asians.
Figure 4
Figure 4. Forest plot of overall survival associated with Ezrin in cancer patients among Caucasians.
Figure 5
Figure 5
Begg’s funnel plots for publication bias test of OS (a), DFS (b) and DSS/MFS (c).
See this image and copyright information in PMC

References

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