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Clinical Trial
. 2015 Dec;94(48):e1973.
doi: 10.1097/MD.0000000000001973.

Influence of Metastatic Status and Number of Removed Lymph Nodes on Survival of Patients With Squamous Esophageal Carcinoma

Feng Yuan  1 , Zheng Qingfeng, Wang Jia, Lv Chao, Yan Shi, Wang Yuzhao, An Chao, Yang Yue
Affiliations
Clinical Trial

Influence of Metastatic Status and Number of Removed Lymph Nodes on Survival of Patients With Squamous Esophageal Carcinoma

Feng Yuan et al. Medicine (Baltimore). 2015 Dec.

Abstract

The aim of this study was to determine the impact of lymph node (LN) metastasis conditions on the prognosis of patients with esophageal squamous carcinoma and the minimum number of LNs that should be removed to maximize overall postoperative survival among patients with this specific pathologic subtype. In this study, 312 patients with thoracic squamous esophageal carcinoma who received in-patient thoracic surgery by the same surgeon in our hospital from August 1, 2003 to December 31, 2009 were recruited. Subsequently, Kaplan-Meier methods were used to determine associations between LN metastasis conditions and mortality and between the numbers of LNs removed during esophagectomy and mortality. Cox regression models were used to adjust for potential confounding covariates. According to Kaplan-Meier analyses, the number of metastatic LNs was a good predictor for the prognosis of patients with esophageal squamous carcinoma and the dissection of ≥ 29 LNs during thoracic surgery significantly improved patient survival (P = 0.011).Lymph node metastasis rates may be a significant predictor for the prognosis of patients with esophageal squamous carcinoma. The number of LNs removed during esophagectomy is an independent predictor for the survival of patients with esophageal squamous carcinoma with maximal postoperative survival after the removal of ≥ 29 LNs.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
Kaplan-Meier estimates of mortality base on the number of lymph nodes involved. Significant difference is shown by Kaplan-Meier analyses between groups of patients with and without lymph node metastases (P < 0.001), whereas no significant differences were observed between N1, N2, and N3 groups (P = 0.312).
FIGURE 2
FIGURE 2
Kaplan-Meier estimates of mortality based on the rate of the lymph nodes involved. Significant differences are shown between all patient groups stratified by lymph node metastasis rates (P < 0.001).
FIGURE 3
FIGURE 3
Kaplan-Meier analysis showed significant improvement survival rate with increasing number of dissected lymph nodes.
See this image and copyright information in PMC

References

    1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin 2011; 61:69–90. - PubMed
    1. Corley DA, Buffler PA. Oesophageal and gastric cardia adenocarcinomas: analysis of regional variation using the cancer incidence in five continents database. Int J Epidemiol 2001; 30:1415–1425. - PubMed
    1. National Cancer Center, Disease Prevention and Control Bureau, Minister of Health. Chinese Cancer Registry Annual Report (2012)[In Chinese]. Military Medical Science Press.
    1. Sweet RH. Transthoracic resection of the esophagus and stomach for carcinoma: analysis of postoperative complication, causes of death, and late results of operation. J Ann Surg 1945; 121:272–284. - PMC - PubMed
    1. Lewis I. The surgical treatment of carcinoma of the esophagus. With special reference to a new operation for growth of the middle third[J]. Br J Surg 1946; 34:18–31. - PubMed

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