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. 2015:2015:170987.
doi: 10.1155/2015/170987. Epub 2015 Nov 8.

Association among Fibrinolytic Proteins, Metabolic Syndrome Components, Insulin Secretion, and Resistance in Schoolchildren

Jin-Shuen Chen  1 , Chung-Ze Wu  2 , Nain-Feng Chu  3 , Li-Chien Chang  4 , Dee Pei  5 , Yuh-Feng Lin  6
Affiliations

Association among Fibrinolytic Proteins, Metabolic Syndrome Components, Insulin Secretion, and Resistance in Schoolchildren

Jin-Shuen Chen et al. Int J Endocrinol. 2015.

Abstract

We investigated the role of urokinase plasminogen activator (uPA) and its soluble receptors (suPAR) and plasminogen activator inhibitor-1 (PAI-1) in metabolic syndrome (MetS) components, insulin secretion, and resistance in schoolchildren. We enrolled 387 children, aged 10.3 ± 1.5 years, in Taipei. Anthropometry, fibrinolytic proteins, MetS components, insulin secretion, and resistance were measured. Subjects were divided into normal, overweight, and obese groups. Finally, the relationship between fibrinolytic proteins and metabolic syndrome in boys and girls was analyzed. In boys, PAI-1 was positively associated with body mass index (BMI) percentile, hypertriglyceride, insulin secretion, and resistance. In girls, PAI-1 was positively associated with obesity, hypertriglyceridemia, and insulin secretion. In girls, uPA was positively associated with insulin secretion. suPAR was positively associated with high-sensitivity C-reactive protein in both boys and girls, and with BMI percentile and body fat in girls. The obese boys had higher suPAR and PAI-1 levels than the normal group. The obese girls had higher uPA, suPAR, and PAI-1 than the normal group. Boys and girls with MetS had higher PAI-1. Fibrinolytic proteins, especially PAI-1, are associated with MetS components and insulin secretion in children. Fibrinolytic proteins changes were more likely to occur in girls than in boys.

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Figures

Figure 1
Figure 1
(a) Urokinase plasminogen activator (uPA), (b) soluble urokinase plasminogen activator receptor (suPAR), and (c) plasminogen activator inhibitor-1 (PAI-1) in normal, overweight, and obese children. The uPA levels in obese girls are higher than in overweight and normal girls. In addition, suPAR and PAI-1 levels in the obese children are higher than in the normal group in both genders. Mean ± SE; ∗ P < 0.05.
Figure 2
Figure 2
(a) Urokinase plasminogen activator (uPA), (b) soluble urokinase plasminogen activator receptor (suPAR), and (c) plasminogen activator inhibitor-1 (PAI-1) in children with and without metabolic syndrome (MetS). The uPA and suPAR levels are not significantly different between children with and without MetS. However, children with MetS have higher PAI-1 levels. Mean ± SE; ∗ P < 0.05.
See this image and copyright information in PMC

References

    1. Kaur J. A comprehensive review on metabolic syndrome. Cardiology Research and Practice. 2014;2014:21. doi: 10.1155/2014/943162.943162 - DOI - PMC - PubMed
    1. Berenson G. S., Agirbasli M., Nguyen Q. M., Chen W., Srinivasan S. R. Glycemic status, metabolic syndrome, and cardiovascular risk in children. Medical Clinics of North America. 2011;95(2):409–417. doi: 10.1016/j.mcna.2010.11.011. - DOI - PubMed
    1. Plesner T., Behrendt N., Ploug M. Structure, function and expression on blood and bone marrow cells of the urokinase-type plasminogen activator receptor, uPAR. Stem Cells. 1997;15(6):398–408. doi: 10.1002/stem.150398. - DOI - PubMed
    1. Dekkers P. E. P., ten Hove T., te Velde A. A., van Deventer S. J. H., van der Poll T. Upregulation of monocyte urokinase plasminogen activator receptor during human endotoxemia. Infection and Immunity. 2000;68(4):2156–2160. doi: 10.1128/iai.68.4.2156-2160.2000. - DOI - PMC - PubMed
    1. Gyetko M. R., Libre E. A., Fuller J. A., Chen G.-H., Toews G. B. Urokinase is required for T lymphocyte proliferation and activation in vitro. Journal of Laboratory and Clinical Medicine. 1999;133(3):274–288. doi: 10.1016/S0022-2143(99)90084-7. - DOI - PubMed

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