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. 2015 Oct;8(5):e4019.
doi: 10.17795/ijcp-4019. Epub 2015 Oct 27.

Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers: A Triple-Blind, Randomized, Placebo-Controlled Trial

Abbas Javadzadeh Bolouri  1 , Atessa Pakfetrat  1 , Arghavan Tonkaboni  2 , Seyed Amir Aledavood  3 , Mohsen Fathi Najafi  4 , Zahra Delavarian  5 , Mohammad Taghi Shakeri  6 , Azade Mohtashami  3
Affiliations

Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers: A Triple-Blind, Randomized, Placebo-Controlled Trial

Abbas Javadzadeh Bolouri et al. Iran J Cancer Prev. 2015 Oct.

Abstract

Background: Mucositis is one of the acute complications of radiotherapy which can ulcerate oral mucosa and cause severe pain and discomfort which can affect oral normal function. Propolis is a natural source of flavenoid which has antiulcer, antibacterial, antifungal, healing and anti-inflammatory effects. Using such an affordable compound without any bad smell or taste that has reasonable price can help the radiotherapy undergoing patients.

Objectives: Our goal is assessing the preventing and therapeutic effect of propolis in radiotherapy induced mucositis in patients with head and neck cancer.

Patients and methods: In a randomized triple blind clinical trial, 20 patient were selected randomly to swish and swallow 15 ml of water based extract of propolis mouth wash 3 times a day in the case group (n = 10) and 15 ml placebo mouth wash in control group (n = 10). we use NIC-CTC scale for determining mucositis grading.

Results: We use T-test, Man-Whitney, Chi-square, and Friedman as analyzing tests. Case group had significantly (P < 0.05) lower grade of mucositis in all of the follow-ups, but xerostomia is not significantly different in two groups (P > 0.05).

Conclusions: This is a pilot study which shows water based extract of propolis efficiently prevents and heals radiotherapy induced mucositis.

Keywords: Cancer; Mouthwashes; Mucositis; Propolis; Radiotherapy.

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Conflict of interest statement

Conflict of Interest:There is no conflict of interest in this article.

Figures

Figure 1.
Figure 1.. Severity of Mucositis in Each Follow-Up
Figure 2.
Figure 2.. Grading of Mucositis in This Study
Figure 3.
Figure 3.. Case Group in Second Week
Figure 4.
Figure 4.. Control Group in Second Week
Figure 5.
Figure 5.. Case Group in 4th Week
Figure 6.
Figure 6.. Control Group in 4th Week
See this image and copyright information in PMC

References

    1. Little JW. Dental management of the medically compromised patient. Mosby; 1997.
    1. Stewart BW, Kleihues P, International Agency for Research on Cancer . World cancer report. IARC press Lyon; 2003. - PubMed
    1. Silveira A, Gonçalves J, Sequeira T, Ribeiro C, Lopes C, Monteiro E, et al. Oncologia de Cabeça e Pescoço: enquadramento epidemiológico e clínico na avaliação da Qualidade de Vida Relacionada com a Saúde. Revista Brasileira de Epidemiologia. 2012;15(1):38–48. doi: 10.1590/s1415-790x2012000100004. - DOI - PubMed
    1. Petersen PE. The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Community Dent Oral Epidemiol. 2003;31 Suppl 1:3–23. - PubMed
    1. Scully C, Epstein JB. Oral health care for the cancer patient. Eur J Cancer B Oral Oncol. 1996;32B(5):281–92. - PubMed

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