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Review
. 2016 Feb;37(2):1445-50.
doi: 10.1007/s13277-015-4514-8. Epub 2015 Dec 3.

The roles of microRNAs in Wilms' tumors

Xin Yu  1 , Zheng Li  2 , Matthew T V Chan  3 , William Ka Kei Wu  3   4
Affiliations
Free article
Review

The roles of microRNAs in Wilms' tumors

Xin Yu et al. Tumour Biol. 2016 Feb.
Free article

Abstract

Wilms' tumor is the most common renal tumor in children in which diffusely anaplastic or unfavorable histology foreshadows poor prognosis. MicroRNAs are small, non-coding RNAs that negatively regulate gene expression at the posttranscriptional level. Accumulating evidence shows that microRNA dysregulation takes part in the pathogenesis of many renal diseases, such as chronic kidney diseases, polycystic kidney disease, renal fibrosis, and renal cancers. In Wilms' tumor, dysregulation of some key oncogenic or tumor-suppressing microRNAs, such as miR-17~92 cluster, miR-185, miR-204, and miR-483, has been documented. In this review, we will summarize current evidence on the role of dysregulated microRNAs in the development of Wilms' tumor.

Keywords: MicroRNAs; Nephroblastoma; Wilms’ tumor.

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