Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 May;11(3):525-530.
doi: 10.1177/1557988315620467. Epub 2015 Dec 3.

Effects of Two Different Dosages of Sildenafil on Patients With Erectile Dysfunction

Affiliations

Effects of Two Different Dosages of Sildenafil on Patients With Erectile Dysfunction

Hongjun Li et al. Am J Mens Health. 2017 May.

Abstract

To investigate the effects of two different dosages of sildenafil on patients with erectile dysfunction (ED), a total of 3,674 patients with ED were recruited to answer questionnaires designed specifically for this study. There were 977 patients in the 50 mg group and there were 2,697 patients in the 100 mg group. Both 50 mg and 100 mg of sildenafil therapy increased the ED patients' average monthly frequency of sexual intercourse, improved erectile function state in self-assessment, and elevated sexual satisfaction and enjoyment. Despite a higher rate of concomitant diseases, patients in the higher dosage of sildenafil group had a better outcome in the average monthly frequency of sexual intercourse and sexual enjoyment compared with those in the lower dosage. Such a study might be helpful for health care providers to choose sildenafil dosage for patients with ED.

Keywords: dose; erectile dysfunction; sildenafil; therapeutic effect.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
The change on sexual frequency after sildenafil treatment.
Figure 2.
Figure 2.
The change on sexual life satisfactory degree after sildenafil treatment.
Figure 3.
Figure 3.
The change on sexual enjoyment after sildenafil treatment.

References

    1. Akand M., Gencer E., Yaman O., Erisgen G., Tekin D., Ozdiler E. (2015). Effect of sildenafil on platelet function and platelet cGMP of patients with erectile dysfunction. Andrologia, 47, 1098-1102. doi:10.1111/and.12387 - DOI - PubMed
    1. Bai W. J., Li H. J., Dai Y. T., He X. Y., Huang Y. R., Liu J. H., . . . Wang X. F. (2015). An open-label, multicenter, randomized, crossover study comparing sildenafil citrate and tadalafil for treating erectile dysfunction in Chinese men naïve to phosphodiesterase 5 inhibitor therapy. Asian Journal of Andrology, 17, 61-67. doi:10.4103/1008-682X.143244 - DOI - PMC - PubMed
    1. Corona G., Rastrelli G., Maseroli E., Forti G., Maggi M. (2013). Sexual function of the ageing male. Best Practice & Research: Clinical Endocrinology & Metabolism, 27, 581-601. doi:10.1016/j.beem.2013.05.007 - DOI - PubMed
    1. da Silva F. H., Pereira M. N., Franco-Penteado C. F., De Nucci G., Antunes E., Claudino M. A. (2013). Phosphodiesterase-9 (PDE9) inhibition with BAY 73-6691 increases corpus cavernosum relaxations mediated by nitric oxide-cyclic GMP pathway in mice. International Journal of Impotence Research, 25, 69-73. doi:10.1038/ijir.2012.35 - DOI - PubMed
    1. Gareri P., Castagna A., Francomano D., Cerminara G., De Fazio P. (2014). Erectile dysfunction in the elderly: An old widespread issue with novel treatment perspectives. International Journal of Endocrinology, 2014, 878670. doi:10.1155/2014/878670 - DOI - PMC - PubMed

LinkOut - more resources