Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2015 Dec 4;117(12):984-6.
doi: 10.1161/CIRCRESAHA.115.307795.

Role of Subplasmalemmal Mitochondria in Angiotensin II-Mediated Contraction

Kely L Sheldon  1 , Alejandra San Martín  2
Affiliations
Editorial

Role of Subplasmalemmal Mitochondria in Angiotensin II-Mediated Contraction

Kely L Sheldon et al. Circ Res. .
No abstract available

Keywords: Editorials; NADPH oxidase; angiotensins; mitochondria; muscle, smooth, vascular; protein kinase C.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Mitochondria amplify ROS leading to activation of L-type Calcium Channels
Upon stimulation, the AT1R receptor activates a Nox1-based NADPH oxidase, leading to the formation of O2•-. Superoxide is dis-mutated into more stable H2O2, which stimulates ROS production in the local mitochondria, leading to an amplification of ROS signaling. H2O2 activates L-Type Calcium Channels by way of PKC oxidative activation, leading to calcium influx and subsequently, contraction.
See this image and copyright information in PMC

Comment on

References

    1. Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T. Requirement for generation of h2o2 for platelet-derived growth factor signal transduction. Science. 1995;270:296–299. - PubMed
    1. Clempus RE, Sorescu D, Dikalova AE, Pounkova L, Jo P, Sorescu GP, Schmidt HH, Lassegue B, Griendling KK. Nox4 is required for maintenance of the differentiated vascular smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol. 2007;27:42–48. - PMC - PubMed
    1. Griendling KK, Ushio-Fukai M. Redox control of vascular smooth muscle proliferation. J Lab Clin Med. 1998;132:9–15. - PubMed
    1. Ardanaz N, Beierwaltes WH, Pagano PJ. Distinct hydrogen peroxide-induced constriction in multiple mouse arteries: Potential influence of vascular polarization. Pharmacol Rep. 2008;60:61–67. - PubMed
    1. San Martin A, Griendling KK. Redox control of vascular smooth muscle migration. Antioxid Redox Signal. 2010;12:625–640. - PMC - PubMed

MeSH terms