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. 2015 Dec;25(6):e3885.
doi: 10.5812/ijp.3885. Epub 2015 Dec 23.

Oxidative Status in Epileptic Children Using Carbamazepine

Murat Tutanc  1 , Mustafa Aras  2 , Recep Dokuyucu  3 , Murat Altas  2 , Cem Zeren  4 , Vefik Arica  1 , Oktay Hasan Ozturk  5 , Sedat Motor  6 , Cahide Yilmaz  1
Affiliations

Oxidative Status in Epileptic Children Using Carbamazepine

Murat Tutanc et al. Iran J Pediatr. 2015 Dec.

Abstract

Background: There is an increasing attention towards the relationship between oxidative stress and epilepsy. The effect of antiepileptic drugs on oxidant status is of major interest. Antiepileptic drugs can increase levels of free radicals, which consequently might lead to seizures. Carbamazepine (CBZ) is an antiepileptic drug commonly used in childhood and adolescence.

Objectives: Therefore we aimed to investigate the effects of CBZ on total antioxidant status, total oxidant stress, and oxidative stress index.

Patients and methods: The study included 40 epileptic patients and 31 healthy children between 4 and 12 years of age. Serum CBZ level, total antioxidant capacity and total oxidant status were measured. Oxidative stress index was also calculated both in controls and patients.

Results: In the epileptic group, decreased levels of total antioxidant capacity, increased total oxidative stress and oxidative stress index levels were found. Positive correlation between plasma CBZ levels and total oxidant status was observed.

Conclusions: Antioxidant action could not be playing any role in antiepileptic effect of CBZ. Furthermore, increased oxidative stress induced by CBZ could be the cause of CBZ-induced seizures. Therefore combining CBZ with antioxidants could be beneficial.

Keywords: Antioxidant Capacity; Carbamazepine; Oxidant Status.

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Figures

Figure 1.
Figure 1.. Positive Correlation Between Plasma Level of CBZ and TOS (r = 0.472, P < 0.01).
CBZ: carbamazepine; TOS: total oxidant status.
See this image and copyright information in PMC

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