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Comment
. 2015 Dec 1;22(6):954-6.
doi: 10.1016/j.cmet.2015.11.006.

SCFAs Take a Toll En Route to Metabolic Syndrome

André Marette  1 , Christian Jobin  2
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SCFAs Take a Toll En Route to Metabolic Syndrome

André Marette et al. Cell Metab. .
Free article

Abstract

Gut dysbiosis is associated with development of metabolic syndrome in Tlr5(-/-) mice, but the underlying mechanism remains unclear. In this issue, Singh et al. (2015) report that augmented SCFA levels play a deleterious role in metabolic syndrome by promoting conversion of SFA to oleate in Tlr5(-/-) mice via increased liver SCD1expression.

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