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Comment
. 2015 Dec 1;22(6):956-8.
doi: 10.1016/j.cmet.2015.11.008.

Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?

Maria Peiris-Pagès  1 , Ubaldo E Martinez-Outschoorn  2 , Federica Sotgia  1 , Michael P Lisanti  3
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Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?

Maria Peiris-Pagès et al. Cell Metab. .
Free article

Abstract

The role of reactive oxygen species (ROS) and antioxidants in cancer is controversial because of their context-dependent ability to promote or suppress tumorigenesis. Piskounova et al. (2015) now show that ROS limit distant metastasis: only cells with increased antioxidant capacity are able to succeed in their purpose to metastasize.

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