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Comment
. 2015 Dec 3;17(6):637-638.
doi: 10.1016/j.stem.2015.11.009.

Direct Conversion Provides Old Neurons from Aged Donor's Skin

Philipp Koch  1
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Direct Conversion Provides Old Neurons from Aged Donor's Skin

Philipp Koch. Cell Stem Cell. .
Free article

Abstract

Modeling human neuronal aging at a cellular level remains challenging. Human neurons are accessible from iPSCs, but during reprogramming age-associated traits of somatic cells get lost. In this issue of Cell Stem Cell, Mertens et al. (2015) demonstrate that neurons obtained by direct cell conversion retain age-associated transcriptional traits and functional deficits of the donor cell population.

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