Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Feb:64:29-36.
doi: 10.1016/j.bioorg.2015.11.006. Epub 2015 Nov 23.

Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies

Nik Khairunissa Nik Abdullah Zawawi  1 , Muhammad Taha  2 , Norizan Ahmat  3 , Abdul Wadood  4 , Nor Hadiani Ismail  1 , Fazal Rahim  5 , Syed Sikander Azam  6 , Noraishah Abdullah  7
Affiliations

Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies

Nik Khairunissa Nik Abdullah Zawawi et al. Bioorg Chem. 2016 Feb.

Abstract

Newly synthesized benzimidazole hydrazone derivatives 1-26 were evaluated for their α-glucosidase inhibitory activity. Compounds 1-26 exhibited varying degrees of yeast α-glucosidase inhibitory activity with IC50 values between 8.40 ± 0.76 and 179.71 ± 1.11 μM when compared with standard acarbose. In this assay, seven compounds that showed highest inhibitory effects than the rest of benzimidazole series were identified. All the synthesized compounds were characterized by different spectroscopic methods adequately. We further evaluated the interaction of the active compounds with enzyme with the help of docking studies.

Keywords: Benzimidazole; Hydrazone; In silico studies; α-Glucosidase activity.

PubMed Disclaimer

MeSH terms

LinkOut - more resources