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Comment
. 2015 Dec 3;163(6):1308-10.
doi: 10.1016/j.cell.2015.11.033.

A Metabolic Switch for Th17 Pathogenicity

Fred P Davis  1 , Yuka Kanno  2 , John J O'Shea  3
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A Metabolic Switch for Th17 Pathogenicity

Fred P Davis et al. Cell. .
Free article

Abstract

T helper 17 (Th17) cells are critical for host defense but can also drive autoimmunity. This divergent behavior is explored by Gaublomme et al. and Wang et al., who identify inflammation-associated genes by measuring gene expression in nearly 1,000 individual Th17 cells and show that CD5L affects the expression of pro-inflammatory genes by altering lipid synthesis.

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