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Comment
. 2015 Dec 3;163(6):1310-2.
doi: 10.1016/j.cell.2015.11.041.

Interleukin-18: The Bouncer at the Mucosal Bar

Timothy W Hand  1
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Free article
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Interleukin-18: The Bouncer at the Mucosal Bar

Timothy W Hand. Cell. .
Free article

Abstract

The fidelity of the intestinal barrier is critical to maintaining a healthy relationship between the immune system and the microbiota. Levy et al. and Nowarski et al. reveal how microbiota-derived metabolites modulate the activation of the inflammasome to influence the expression of the cytokine IL-18, intestinal barrier function, and intestinal inflammation.

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