Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Dec;57(12):1331-6.
doi: 10.1097/JOM.0000000000000561.

N-Acetyltransferase 2 Genotypes Are Associated With Diisocyanate-Induced Asthma

Berran Yucesoy  1 , Grace E Kissling, Victor J Johnson, Zana L Lummus, Denyse Gautrin, André Cartier, Louis-Philippe Boulet, Joaquin Sastre, Santiago Quirce, Susan M Tarlo, Maria-Jesus Cruz, Xavier Munoz, Michael I Luster, David I Bernstein
Affiliations

N-Acetyltransferase 2 Genotypes Are Associated With Diisocyanate-Induced Asthma

Berran Yucesoy et al. J Occup Environ Med. 2015 Dec.

Abstract

Objective: To investigate whether genetic variants of N-acetyltransferase (NAT) genes are associated with diisocyanate asthma (DA).

Methods: The study population consisted of 354 diisocyanate-exposed workers. Genotyping was performed using a 5'-nuclease polymerase chain reaction assay.

Results: The NAT2 rs2410556 and NAT2 rs4271002 variants were significantly associated with DA in the univariate analysis. In the first logistic regression model comparing DA+ and asymptomatic worker groups, the rs2410556 (P = 0.004) and rs4271002 (P < 0.001) single nucleotide polymorphisms and the genotype combination, NAT2 rs4271002*NAT1 rs11777998, showed associations with DA risk (P = 0.014). In the second model comparing DA+ and DA- groups, NAT2 rs4271002 variant and the combined genotype, NAT1 rs8190845*NAT2 rs13277605, were significantly associated with DA risk (P = 0.022, P = 0.036, respectively).

Conclusions: These findings suggest that variations in the NAT2 gene and their interactions contribute to DA susceptibility.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interests declared.

References

    1. Bakerly ND, Moore VC, Vellore AD, et al. Fifteen-year trends in occupational asthma: data from the Shield surveillance scheme. Occup Med (Lond) 2008;58:169–174. - PubMed
    1. Bernstein DI. Genetics of occupational asthma. Curr Opin Allergy Clin Immunol. 2011;11:86–89. - PubMed
    1. CDC. 2014 http://www.cdc.gov/niosh/topics/isocyanates/
    1. Booth K, Cummings B, Karoly WJ, et al. Measurements of airborne methylene diphenyl diisocyanate (MDI) concentration in the U.S. workplace. J Occup Environ Hyg. 2009;6:228–238. - PubMed
    1. Campo P, Aranda A, Rondon C, et al. Work-related sensitization and respiratory symptoms in carpentry apprentices exposed to wood dust and diisocyanates. Ann Allergy Asthma Immunol. 2010;105:24–30. - PubMed

Publication types