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Meta-Analysis
. 2015 Dec;110(3):e13-7.
doi: 10.1016/j.diabres.2015.10.014. Epub 2015 Oct 23.

Incretin-based therapies are associated with acute pancreatitis: Meta-analysis of large randomized controlled trials

Pavel S Roshanov  1 , Brittany B Dennis  2
Affiliations
Meta-Analysis

Incretin-based therapies are associated with acute pancreatitis: Meta-analysis of large randomized controlled trials

Pavel S Roshanov et al. Diabetes Res Clin Pract. 2015 Dec.

Abstract

Previous studies have offered weak and conflicting evidence regarding the impact of incretin-based oral antihyperglycemic agents on risk of acute pancreatitis. This meta-analysis of three recent mega-trials found an 82% increase in the odds of acute pancreatitis with the use of these agents compared to usual care (95% CI, 1.17-2.82).

Keywords: Acute pancreatitis; DDP4 inhibitors; Gliptins; Incretins; Safety.

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