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Comment
. 2015 Dec 22;112(51):15536-7.
doi: 10.1073/pnas.1521670112. Epub 2015 Dec 7.

Stepping toward therapeutic CRISPR

Keith T Gagnon  1 , David R Corey  2
Affiliations
Comment

Stepping toward therapeutic CRISPR

Keith T Gagnon et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Conflict of interest statement: D.R.C. has collaborated with Dr. Prakash within the past 48 months.

Figures

Fig. 1.
Fig. 1.
Potential approach to synthetic CRISPR-Cas9 therapeutics envisioned by Rahdar et al. (5).
See this image and copyright information in PMC

Comment on

References

    1. Elbashir SM, et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 2001;411(6836):494–498. - PubMed
    1. Borna H, Imani S, Iman M, Azimzadeh Jamalkandi S. Therapeutic face of RNAi: In vivo challenges. Expert Opin Biol Ther. 2015;15(2):269–285. - PubMed
    1. Kubowicz P, Żelaszczyk D, Pękala E. RNAi in clinical studies. Curr Med Chem. 2013;20(14):1801–1816. - PubMed
    1. Kanasty R, Dorkin JR, Vegas A, Anderson D. Delivery materials for siRNA therapeutics. Nat Mater. 2013;12(11):967–977. - PubMed
    1. Rahdar M, et al. Synthetic CRISPR RNA-Cas9–guided genome editing in human cells. Proc Natl Acad Sci USA. 2015;112:E7110–E7117. - PMC - PubMed

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