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. 2015 Oct;59(10):664-9.
doi: 10.4103/0019-5049.167484.

Reversal agents in anaesthesia and critical care

Nibedita Pani  1 , Pradeep A Dongare  2 , Rajeeb Kumar Mishra  1
Affiliations

Reversal agents in anaesthesia and critical care

Nibedita Pani et al. Indian J Anaesth. 2015 Oct.

Abstract

Despite the advent of short and ultra-short acting drugs, an in-depth knowledge of the reversal agents used is a necessity for any anaesthesiologist. Reversal agents are defined as any drug used to reverse the effects of anaesthetics, narcotics or potentially toxic agents. The controversy on the routine reversal of neuromuscular blockade still exists. The advent of newer reversal agents like sugammadex have made the use of steroidal neuromuscular blockers like rocuronium feasible in rapid sequence induction situations. We made a review of the older reversal agents and those still under investigation for drugs that are regularly used in our anaesthesia practice.

Keywords: Flumazenil; naloxone; platelet factor 4; sugammadex.

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Figures

Figure 1
Figure 1
Structure of Sugammadex
Figure 2
Figure 2
Sugammadex encapsulating rocuronium
See this image and copyright information in PMC

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