Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Dec 9:15:253.
doi: 10.1186/s12883-015-0505-z.

Factors for short-term outcomes in patients with a minor stroke: results from China National Stroke Registry

Lingyun Wu  1 , Anxin Wang  2   3   4   5   6 , Xianwei Wang  7   8   9   10 , Xingquan Zhao  11   12   13   14 , Chunxue Wang  15   16   17   18 , Liping Liu  19   20   21   22 , Huaguang Zheng  23   24   25   26 , Yongjun Wang  27   28   29   30 , Yibin Cao  31 , Yilong Wang  32   33   34   35 ; China National Stroke Registry investigators
Collaborators, Affiliations

Factors for short-term outcomes in patients with a minor stroke: results from China National Stroke Registry

Lingyun Wu et al. BMC Neurol. .

Abstract

Background: Stroke recurrence and disability in patients with a minor stroke is one of the most depressing medical situations. In this study, we aimed to identify which factors were associated with adverse outcomes of a minor stroke.

Methods: The China National Stroke Registry (CNSR) is a nationwide prospective registry for patients presented to hospitals with acute cerebrovascular events between September 2007 and August 2008. The 3-month follow-up was completed in 4669 patients with a minor stroke defined as the initial neurological severity lower than 4 in the National Institutes of Health Stroke Scale (NIHSS). Multivariate model was used to determine the association between risk factors and clinical outcomes.

Results: Of 4669 patients with a minor stroke during 3-month follow-up, 459 (9.8 %) patients experienced recurrent stroke, 679 (14.5 %) had stroke disability and 168 (3.6 %) died. Multivariate model identified hypertension, diabetes mellitus, atrial fibrillation, coronary heart disease and previous stroke as independent predictors for the recurrent stroke. Age, diabetes mellitus, atrial fibrillation, previous stroke and time from onset to admission < 24 h were independent predictors for stroke disability. The independent predictors for the all-caused death were age, atrial fibrillation, and coronary heart disease.

Conclusions: The short-term risk of poor clinical outcome in Chinese patients with a minor stroke was substantial. Therefore, patients with a minor stroke should be given expeditious assessment and urgent aggressive intervention.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Flow chart showing the patient selection. NIHSS, National Institutes of Health Stroke Scale
Fig. 2
Fig. 2
The adjusted ORs for stroke recurrence, disability and death at 3 months after stroke onset. Stroke disability was defined as modified Rankin Scale > =3.OR denotes Odds Ratio; CI, Confidence Internal; BMI, Body Mass Index. Adjusted for age, gender, hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, coronary heart disease, previous stroke, current or previous smoking, moderate or heavy alcohol, BMI at admission, and admission within 24 h
See this image and copyright information in PMC

References

    1. Chen Z. The third national survey on the cause of death. Beijing, China: Peking Union Medical University Press; 2008.
    1. Liu M, Wu B, Wang WZ, Lee LM, Zhang SH, Kong LZ. Stroke in China: epidemiology, prevention, and management strategies. Lancet Neurol. 2007;6(5):456–64. doi: 10.1016/S1474-4422(07)70004-2. - DOI - PubMed
    1. Zhao D, Liu J, Wang W, Zeng Z, Cheng J, Liu J, et al. Epidemiological transition of stroke in China: twenty-one-year observational study from the Sino-MONICA-Beijing Project. Stroke. 2008;39(6):1668–74. doi: 10.1161/STROKEAHA.107.502807. - DOI - PubMed
    1. Coutts SB, Modi J, Patel SK, Aram H, Demchuk AM, Goyal M, et al. What causes disability after transient ischemic attack and minor stroke?: Results from the CT and MRI in the Triage of TIA and minor Cerebrovascular Events to Identify High Risk Patients (CATCH) Study. Stroke. 2012;43(11):3018–22. doi: 10.1161/STROKEAHA.112.665141. - DOI - PubMed
    1. Smith EE, Abdullah AR, Petkovska I, Rosenthal E, Koroshetz WJ, Schwamm LH. Poor outcomes in patients who do not receive intravenous tissue plasminogen activator because of mild or improving ischemic stroke. Stroke. 2005;36(11):2497–9. doi: 10.1161/01.STR.0000185798.78817.f3. - DOI - PubMed