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. 2016 Jun;144(8):1784-91.
doi: 10.1017/S0950268815002885. Epub 2015 Dec 9.

The global burden of major infectious complications following prostate biopsy

H Y Bennett  1 , M J Roberts  1 , S A R Doi  2 , R A Gardiner  1
Affiliations

The global burden of major infectious complications following prostate biopsy

H Y Bennett et al. Epidemiol Infect. 2016 Jun.

Abstract

We present a systematic review providing estimates of the overall and regional burden of infectious complications following prostate biopsy. A directly standardized prevalence estimate was used because it reflects the burden of disease more explicitly. Complications included sepsis, hospitalization, bacteraemia, bacteriuria, and acute urinary retention after biopsy. There were 165 articles, comprising 162 577 patients, included in the final analysis. Our findings demonstrate that transrectal biopsy was associated with a higher burden of hospitalization (1·1% vs. 0·9%) and sepsis (0·8% vs. 0·1%) compared to transperineal biopsy, while acute urinary retention was more prevalent after transperineal than transrectal biopsy (4·2% vs. 0·9%). The differences were statistically non-significant because of large heterogeneity across countries. We also demonstrate and discuss regional variations in complication rates, with Asian studies reporting higher rates of sepsis and hospitalization.

Keywords: Infection; post-operative complications; prostate biopsy; prostatic neoplasms; transperineal; transrectal.

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Figures

Fig. 1.
Fig. 1.
PRISMA flow diagram of study selection. From the initial 3952 citations, 165 articles were included in the final analysis.
See this image and copyright information in PMC

References

    1. GLOBOCAN 2012. Cancer incidence and mortality worldwide: IARC CancerBase No. 11 database (http://globocan.iarc.fr). International Agency for Research on Cancer; 2013. Accessed 14 March 2014.
    1. Loeb S, et al. Systematic review of complications of prostate biopsy. European Urology 2013; 64: 876–892. - PubMed
    1. Djavan B, et al. Safety and morbidity of first and repeat transrectal ultrasound guided prostate needle biopsies: results of a prospective European prostate cancer detection study. Journal of Urology 2001; 166: 856–860. - PubMed
    1. Roberts MJ, et al. Baseline prevalence of antimicrobial resistance and subsequent infection following prostate biopsy using empirical or altered prophylaxis: a bias-adjusted meta-analysis. International Journal of Antimicrobial Agents 2014; 43: 301–309. - PubMed
    1. Williamson DA, et al. Infectious complications following transrectal ultrasound-guided prostate biopsy: new challenges in the era of multidrug-resistant Escherichia coli. Clinical Infectious Diseases 2013; 57: 267–274. - PubMed

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