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Review
. 2016 Jan;5(1):88-99.
doi: 10.1002/cam4.566. Epub 2015 Dec 9.

Distal bile duct carcinomas and pancreatic ductal adenocarcinomas: postulating a common tumor entity

Rosa B Schmuck  1 , Cynthia V de Carvalho-Fischer  1 , Christopher Neumann  1 , Johann Pratschke  1 , Marcus Bahra  1
Affiliations
Review

Distal bile duct carcinomas and pancreatic ductal adenocarcinomas: postulating a common tumor entity

Rosa B Schmuck et al. Cancer Med. 2016 Jan.

Abstract

The set definition of distal cholangiocarcinomas and adenocarcinomas of the pancreatic head is challenged by their close anatomical relation, similar growth pattern, and corresponding therapeutic outcome. They show a mutual development during embryologic organ formation and share phenotypic characteristics. This review will highlight the similarities with regard to the common origin of their primary organs, histopathological similarities, and modern clinical management. Thus, we propose to subsume those entities under a common superfamily.

Keywords: Bile duct neoplasm; cholangiocarcinoma; pancreatic neoplasm.

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Figures

Figure 1
Figure 1
Pancreas divisum with main pancreatic duct and duct of Santorini in endoscopic retrograde cholangiopancreatography.
Figure 2
Figure 2
Biliary preneoplastic lesions and pancreatic precurser lesions share common characteristics. Both, PanINs (Intraepithelial neoplasia of the pancreas) and IPMNs (intraductal papillary mucinous neoplasms) have a corresponding counterpart in the biliary tract: BilINs (Biliary intraepithelial neoplasia) and IPNBs (intraductal papillary neoplasm of the biliary tract).
Figure 3
Figure 3
Tumors are classified according to their location (from top to bottom): intrahepatic cholangiocarcinoma (IH‐CC), hilar cholangiocarcinoma, distal cholangiocarcinoma (dCC), and adenocarcinoma of the pancreas (PDAC).
See this image and copyright information in PMC

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MeSH terms