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Multicenter Study
. 2016 Feb;45(2):311-6.
doi: 10.1097/MPA.0000000000000392.

Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis

Robert R McWilliams  1 , Patrick Maisonneuve, William R Bamlet, Gloria M Petersen, Donghui Li, Harvey A Risch, Herbert Yu, Elizabeth T H Fontham, Brian Luckett, Cristina Bosetti, Eva Negri, Carlo La Vecchia, Renato Talamini, H Bas Bueno de Mesquita, Paige Bracci, Steven Gallinger, Rachel E Neale, Albert B Lowenfels
Affiliations
Multicenter Study

Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis

Robert R McWilliams et al. Pancreas. 2016 Feb.

Abstract

Objectives: While pancreatic cancer (PC) most often affects older adults, to date, there has been no comprehensive assessment of risk factors among PC patients younger than 60 years.

Methods: We defined early-onset PC (EOPC) and very-early-onset PC (VEOPC) as diagnosis of PC in patients younger than 60 and 45 years, respectively. We pooled data from 8 case-control studies, including 1954 patients with EOPC and 3278 age- and sex-matched control subjects. Logistic regression analysis was performed to identify associations with EOPC and VEOPC.

Results: Family history of PC, diabetes mellitus, smoking, obesity, and pancreatitis were associated with EOPC. Alcohol use equal to or greater than 26 g daily also was associated with increased risk of EOPC (odds ratio, 1.49; 95% confidence interval, 1.21-1.84), and there appeared to be a dose- and age-dependent effect of alcohol on risk. The point estimate for risk of VEOPC was an odds ratio of 2.18 (95% confidence interval, 1.17-4.09).

Conclusions: The established risk factors for PC, including smoking, diabetes, family history of PC, and obesity, also apply to EOPC. Alcohol intake appeared to have an age-dependent effect; the strongest association was with VEOPC.

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Conflict of interest statement

Conflict of Interest: The authors have declared no conflicts of interest

Figures

Figure 1
Figure 1
Univariate forest plot with odds ratios and confidence intervals for daily average alcohol exposure (g ethanol/day) and risk of early onset (
See this image and copyright information in PMC

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