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Controlled Clinical Trial
. 2015 Nov 23:10:2549-57.
doi: 10.2147/COPD.S81363. eCollection 2015.

Effects of 12 weeks of aerobic training on autonomic modulation, mucociliary clearance, and aerobic parameters in patients with COPD

Marceli Rocha Leite  1 , Ercy Mara Cipulo Ramos  1 , Carlos Augusto Kalva-Filho  2 , Ana Paula Coelho Figueira Freire  1 , Bruna Spolador de Alencar Silva  1 , Juliana Nicolino  1 , Alessandra Choqueta de Toledo-Arruda  3 , Marcelo Papoti  4 , Luiz Carlos Marques Vanderlei  1 , Dionei Ramos  1
Affiliations
Controlled Clinical Trial

Effects of 12 weeks of aerobic training on autonomic modulation, mucociliary clearance, and aerobic parameters in patients with COPD

Marceli Rocha Leite et al. Int J Chron Obstruct Pulmon Dis. .

Abstract

Introduction: Patients with chronic obstructive pulmonary disease (COPD) exhibit aerobic function, autonomic nervous system, and mucociliary clearance alterations. These parameters can be attenuated by aerobic training, which can be applied with continuous or interval efforts. However, the possible effects of aerobic training, using progressively both continuous and interval sessions (ie, linear periodization), require further investigation.

Aim: To analyze the effects of 12-week aerobic training using continuous and interval sessions on autonomic modulation, mucociliary clearance, and aerobic function in patients with COPD.

Methods: Sixteen patients with COPD were divided into an aerobic (continuous and interval) training group (AT) (n=10) and a control group (CG) (n=6). An incremental test (initial speed of 2.0 km·h(-1), constant slope of 3%, and increments of 0.5 km·h(-1) every 2 minutes) was performed. The training group underwent training for 4 weeks at 60% of the peak velocity reached in the incremental test (vVO2peak) (50 minutes of continuous effort), followed by 4 weeks of sessions at 75% of vVO2peak (30 minutes of continuous effort), and 4 weeks of interval training (5×3-minute effort at vVO2peak, separated by 1 minute of passive recovery). Intensities were adjusted through an incremental test performed at the end of each period.

Results: The AT presented an increase in the high frequency index (ms(2)) (P=0.04), peak oxygen uptake (VO2peak) (P=0.01), vVO2peak (P=0.04), and anaerobic threshold (P=0.02). No significant changes were observed in the CG (P>0.21) group. Neither of the groups presented changes in mucociliary clearance after 12 weeks (AT: P=0.94 and CG: P=0.69).

Conclusion: Twelve weeks of aerobic training (continuous and interval sessions) positively influenced the autonomic modulation and aerobic parameters in patients with COPD. However, mucociliary clearance was not affected by aerobic training.

Keywords: COPD; aerobic treatment; exercise; mucociliary clearance.

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Figures

Figure 1
Figure 1
Flow diagram showing the participation of the patients in the study.
Figure 2
Figure 2
Time spent in each intensity zone during the 12 weeks of aerobic training. Notes: Z1: 60% of VO2peak for 50 minutes (continuous effort); Z2: 75% of VO2peak for 30 minutes (continuous effort); Z3: five efforts lasting 3 minutes separated by 1 minute of passive recovery (interval effort). Abbreviation: VO2peak, peak oxygen uptake.
Figure 3
Figure 3
Box plot of saccharin transit time (STT) test of the aerobic training group (AT) and the no-training control group (CG), observed at baseline (M0) and after 12 weeks (M1).
See this image and copyright information in PMC

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