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Review
. 2015 Dec 1:6:1336.
doi: 10.3389/fmicb.2015.01336. eCollection 2015.

Alternatives to Antibiotics to Prevent Necrotic Enteritis in Broiler Chickens: A Microbiologist's Perspective

Delphine L Caly  1 , Romain D'Inca  2 , Eric Auclair  2 , Djamel Drider  1
Affiliations
Review

Alternatives to Antibiotics to Prevent Necrotic Enteritis in Broiler Chickens: A Microbiologist's Perspective

Delphine L Caly et al. Front Microbiol. .

Abstract

Since the 2006 European ban on the use of antibiotics as growth promoters in animal feed, numerous studies have been published describing alternative strategies to prevent diseases in animals. A particular focus has been on prevention of necrotic enteritis in poultry caused by Clostridium perfringens by the use of microbes or microbe-derived products. Microbes produce a plethora of molecules with antimicrobial properties and they can also have beneficial effects through interactions with their host. Here we review recent developments in novel preventive treatments against C. perfringens-induced necrotic enteritis in broiler chickens that employ yeasts, bacteria and bacteriophages or secondary metabolites and other microbial products in disease control.

Keywords: Clostridium perfringens; antimicrobials; bacteriocin; broiler chicken; competitive exclusion; necrotic enteritis; probiotic.

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Figures

Figure 1
Figure 1
Identification of C. perfringens virulence and pathogenicity factors as potential targets for NE prevention. C. perfringens virulence and pathogenicity factors are represented as colored boxes. Antagonistic action of the microbes and microbe-derived products discussed in this review are represented by flat-end arrows.
See this image and copyright information in PMC

References

    1. Abudabos A. M., Yehia H. M. (2013). Effect of dietary mannan oligosaccharide from Saccharomyces cerevisiae on live performance of broilers under Clostridium perfringens challenge. Ital. J. Anim. Sci. 12, 231–235. 10.4081/ijas.2013.e38 - DOI
    1. Allaart J. G., van Asten A. J., Vernooij J. C., Gröne A. (2011). Effect of Lactobacillus fermentum on beta2 toxin production by Clostridium perfringens. Appl. Environ. Microbiol. 77, 4406–4411. 10.1128/AEM.03002-10 - DOI - PMC - PubMed
    1. Al-Sheikhly F., Al-Saieg A. (1980). Role of Coccidia in the occurrence of necrotic enteritis of chickens. Avian Dis. 24, 324–333. 10.2307/1589700 - DOI - PubMed
    1. Annett C. B., Viste J. R., Chirino-Trejo M., Classen H. L., Middleton D. M., Simko E. (2002). Necrotic enteritis: effect of barley, wheat and corn diets on proliferation of Clostridium perfringens type A. Avian Pathol. 31, 598–601. 10.1080/0307945021000024544 - DOI - PubMed
    1. Baba E., Wakeshima H., Fukui K., Fukata T., Arakawa A. (1992). Adhesion of bacteria to the cecal mucosal surface of conventional and germ-free chickens infected with Eimeria tenella. Am. J. Vet. Res. 53, 194–197. - PubMed