Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Oct-Dec;4(4):344-7.
doi: 10.5455/jice.20151012013034. Epub 2015 Nov 5.

Antiviral properties of caffeic acid phenethyl ester and its potential application

Hacı Kemal Erdemli  1 , Sumeyya Akyol  2 , Ferah Armutcu  3 , Omer Akyol  4
Affiliations
Review

Antiviral properties of caffeic acid phenethyl ester and its potential application

Hacı Kemal Erdemli et al. J Intercult Ethnopharmacol. 2015 Oct-Dec.

Abstract

Caffeic acid phenethyl ester (CAPE) is found in a variety of plants and well-known the active ingredient of the honeybee propolis. CAPE showed anti-inflammatory, anticarcinogenic, antimitogenic, antiviral, and immunomodulatory properties in several studies. The beneficial effects of CAPE on different health issues attracted scientists to make more studies on CAPE. Specifically, the anti-viral effects of CAPE and its molecular mechanisms may reveal the important properties of virus-induced diseases. CAPE and its targets may have important roles to design new therapeutics and understand the molecular mechanisms of virus-related diseases. In this mini-review, we summarize the antiviral effects of CAPE under the light of medical and chemical literature.

Keywords: Antiviral effect; caffeic acid phenethyl ester; caffeic acid phenethyl ester-like compounds.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Chemical structure of caffeic acid phenethyl ester
Figure 2
Figure 2
Featured two hypothetical opinions about the antiviral effects of caffeic acid phenethyl ester (CAPE). Integration step is efficiently inhibited by CAPE than the initial cleavage step by HIV-1 integrase (on the left), and CAPE strongly prevents both Tax binding to IκBα and its induced degradation by Tax (on the right)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Sud’ina GF, Mirzoeva OK, Pushkareva MA, Korshunova GA, Sumbatyan NV, Varfolomeev SD. Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett. 1993;329:21–4. - PubMed
    1. Natarajan K, Singh S, Burke TR, Jr, Grunberger D, Aggarwal BB. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci U S A. 1996;93:9090–5. - PMC - PubMed
    1. Park JH, Lee JK, Kim HS, Chung ST, Eom JH, Kim KA, et al. Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice. Int Immunopharmacol. 2004;4:429–36. - PubMed
    1. Akyol S, Ozturk G, Ginis Z, Armutcu F, Yigitoglu MR, Akyol O. In vivo and in vitro antineoplastic actions of caffeic acid phenethyl ester (CAPE): Therapeutic perspectives. Nutr Cancer. 2013;65:515–26. - PubMed
    1. Armutcu F, Akyol S, Ustunsoy S, Turan FF. Therapeutic potential of caffeic acid phenethyl ester and its anti-inflammatory and immunomodulatory effects (Review) Exp Ther Med. 2015;9:1582–8. - PMC - PubMed

LinkOut - more resources