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Comment
. 2015 Dec 7;35(5):529-530.
doi: 10.1016/j.devcel.2015.11.016.

Autophagy Devours the Nuclear Lamina to Thwart Oncogenic Stress

Andrew M Leidal  1 , Jayanta Debnath  2
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Autophagy Devours the Nuclear Lamina to Thwart Oncogenic Stress

Andrew M Leidal et al. Dev Cell. .
Free article

Abstract

A recent study by Dou et al. (2015) in Nature extends the functions of autophagy to the nucleus, where it mediates the degradation of the nuclear lamina upon oncogenic insults to reinforce cellular senescence.

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  • Autophagy mediates degradation of nuclear lamina.
    Dou Z, Xu C, Donahue G, Shimi T, Pan JA, Zhu J, Ivanov A, Capell BC, Drake AM, Shah PP, Catanzaro JM, Ricketts MD, Lamark T, Adam SA, Marmorstein R, Zong WX, Johansen T, Goldman RD, Adams PD, Berger SL. Dou Z, et al. Nature. 2015 Nov 5;527(7576):105-9. doi: 10.1038/nature15548. Epub 2015 Oct 28. Nature. 2015. PMID: 26524528 Free PMC article.

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