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Meta-Analysis
. 2016 Feb:23:109-11.
doi: 10.1016/j.parkreldis.2015.11.026. Epub 2015 Nov 25.

TREM2 rare variant p.R47H is not associated with Parkinson's disease

David Mengel  1 , Mathias Thelen  2 , Monika Balzer-Geldsetzer  1 , Charlotte Söling  1 , Jan-Philipp Bach  3 , Eva Schaeffer  4 , Christine Herold  5 , Tim Becker  6 , Inga Liepelt  4 , Julian Becker  2 , Steffi Riedel-Heller  7 , Martin Scherer  8 , Frank Jessen  9 , Wolfgang Maier  10 , Richard Dodel  1 , Alfredo Ramirez  11
Affiliations
Meta-Analysis

TREM2 rare variant p.R47H is not associated with Parkinson's disease

David Mengel et al. Parkinsonism Relat Disord. 2016 Feb.

Abstract

Variant p.R47H of triggering receptor expressed on myeloid cells 2 (TREM2) has been associated with Parkinson's disease (PD). We screened this TREM2-variant in 821 PD patients including 261 demented PD patients (PDD) and in healthy controls (n = 919). Neither the entire PD nor the small PDD sample was associated with p.R47H.

Keywords: Association; Dementia; Non-motor symptoms; Parkinson's disease; TREM2.

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