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Editorial
. 2016;15(3):303-4.
doi: 10.1080/15384101.2015.1124698. Epub 2015 Dec 10.

MKRN1: Uncovering function by an unbiased systems approach

Richard L Carpenedo  1 , Paul A Cassar  2 , William L Stanford  1   3   4   5
Affiliations
Editorial

MKRN1: Uncovering function by an unbiased systems approach

Richard L Carpenedo et al. Cell Cycle. 2016.
No abstract available

Keywords: MKRN1; Makorin 1; RNA-binding; embryonic stem cells; gene regulatory network; post-transcriptional regulation; systems biology.

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Figures

Figure 1.
Figure 1.
An unbiased systems approach was used to elucidate the role of MKRN1, a regulatory protein in mESCs. Proteomic analyses followed by functional annotation of interacting proteins uncovered a role in RNA-binding. Systems-level analyses of RNA-binding function revealed a role in RNA transport and cell death. Importantly, cellular and molecular assays were performed to confirm the functions inferred from systems-level datasets. We foresee broad applicability of this approach to identify the role of regulatory elements in a variety of cell types.
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Comment on

  • doi: 10.15252/embr.201540974

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