doi: 10.1080/10286020.2015.1102135.
Epub 2015 Dec 10.
New laurane-type sesquiterpenoids from the Chinese red alga Laurencia okamurai Yamada
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- PMID: 26652197
- DOI: 10.1080/10286020.2015.1102135
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New laurane-type sesquiterpenoids from the Chinese red alga Laurencia okamurai Yamada
J Asian Nat Prod Res.
2015.
Abstract
Two new laurane-type sesquiterpenoids, debromo-3α-hydroperoxy-3-epiaplysin (1) and debromo-3β-hydroperoxyaplysin (2), together with seven known related compounds (3-9), were isolated from the Chinese red alga Laurencia okamurai. Their structures were elucidated by detailed analysis of spectroscopic data and by comparison with the literature. In bioassay, compounds 2, 4, 8, and 9 exhibited significant PTP1B inhibitory activity with IC50 values ranging from 4.9 to 14.9 μg/ml.
Keywords: Chinese red algae; Laurencia okamurai; PTP1B inhibitor; laurane; sesquiterpene.
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